Research Information System
in: Exploring the Causes, Prevention and Management of Cardiomyopathy [Working Title], Prof. Ernest Adeghate, Editor, intectopen, London, pp.1-12, 2024
Premature Ventricular Complexes-induced Cardiomyopathy (PVC-CM) is a cardiomyopathy characterized by left ventricular (LV) dysfunction caused by frequent premature ventricular complexes (PVCs), with the potential for resolution with treatment. Although the mechanism of PVC-CM development involves various cellular and intercellular mechanisms along with multiple risk factors, its mechanism has not been fully elucidated. In patients who develop symptomatic and/or LV dysfunction, suppression of PVCs is indicated for treatment. Despite the use of antiarrhythmic drugs in treatment, hesitations regarding their use persist due to common side effects, including proarrhythmia. Recently introduced radiofrequency ablation therapy is both effective and has a high success rate when performed by experienced hands, and current guidelines recommend it as the first option for patients developing LV dysfunction. This review will discuss PVC-CM in detail, alongside current guidelines and studies.