Akademik Veri Yönetim Sistemi
Cumhuriyet Tıp Dergisi (ELEKTRONİK), cilt.41, sa.2, ss.348-356, 2019 (Hakemli Dergi)
Objective: Prediabetes; is the first stage of diabetes. It is a high-risk status for the development of diabetes mellitus type 2, which is an important public health problem. Myocardial performance index (MPI) is a noninvasive method that can be measured by echocardiography showing left ventricular (LV) systolic and diastolic functions. In this study, we aimed to investigate the relationship between prediabetes and MPI.
Method: Fifty-three consecutive patients without chronic illness who were diagnosed with prediabetes and 48 otherwise healthy subjects were enrolled in the study. Fasting blood glucose and HbA1c levels were measured from venous blood samples. MPI values were calculated by tissue Doppler imaging technique for all participants.
Results: In the prediabetic group, the mean fasting blood glucose level was 115 ± 4 mg/dL, whereas in the control group it was 90 ± 5 mg/dL. As expected, HbA1c was statistically significantly higher in the patient group. (% 5,7 ± 0,3 vs % 5,1±0,3, respectively). The MPI values in the patient group were higher than the control group and this difference was statistically significant (0.74 ± 0.12 vs. 0.64 ± 0.09; p<0,001). There were no statistically significant differences between the groups in terms of age, gender, and body mass index.
Conclusions: In prediabetic patients, MPI was higher than the control group, which may be related to impaired LV systolic and diastolic functions.
Keywords: Prediabetes, myocardial performance index, tissue doppler imaging