The effects of melatonin and caffeic acid phenethyl ester (CAPE) on fracture healing under ischemic conditions

ERDEM M., Gülabi D., AŞCI M., Bostan B., Güneş T., Köseoǧlu R. D.

Acta Orthopaedica et Traumatologica Turcica, cilt.48, sa.3, ss.339-345, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3944/aott.2014.3244
  • Dergi Adı: Acta Orthopaedica et Traumatologica Turcica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.339-345
  • Anahtar Kelimeler: Caffeic acid phenethyl ester, Fracture, Free oxygen radicals, Ischemia, Melatonin
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Hayır

Özet

Objective: The aim of this study was to investigate the effects of antioxidant molecules Melatonin and Caffeic Acid Phenethyl Ester (CAPE) on fracture healing under ischemic conditions. Methods: A right tibia fracture was created and fixed with an intramedullary pin in forty four male Wistar-albino rats. The rats were then randomly allocated to fracture, fracture-ischemia, fractureischemia- melatonin, and fracture-ischemia-CAPE groups. Ischemia was created by clamping femoral arteries four and a half hours. Animals were killed and radiographic, histological and biomechanical evaluation was performed sixth week after surgery. Results: The radiological and histological scores of the fracture-ischemia-CAPE group were significantly better than the fracture- ischemia group at 6th week follow-up. Complete radiographical and histological healing of all fractures was detected in all groups. There was a significant difference between the maximum fracture force between the groups (fracture-ischemia