Effects of platelet-rich fibrin and dexamethasone on nerve regeneration after acute facial-nerve injury

Işik Ü. G., Ensari N., Sarikçioğlu L., Sonbay Yilmaz N. D., Yüksel Y., Senirli R. T., ...More

Acta Oto-Laryngologica, vol.143, no.7, pp.623-629, 2023 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 143 Issue: 7
  • Publication Date: 2023
  • Doi Number: 10.1080/00016489.2023.2233085
  • Journal Name: Acta Oto-Laryngologica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Bibliography of Social Sciences, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, Linguistics & Language Behavior Abstracts, Veterinary Science Database
  • Page Numbers: pp.623-629
  • Keywords: Dexamethasone, facial nerve, nerve recovery, platelet-rich fibrin
  • Bilecik Şeyh Edebali University Affiliated: No

Abstract

Background: Acute facial-nerve injury. Objective: To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration. Materials and methods: Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks. Results: The mean eye-closure movement score in Group B was significantly higher than that in Group F (p <.001). The mean whisker-movement score in Group B was significantly higher than that in Group F (p =.001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E (p <.001). Furthermore, an improvement in nerve ultrastructure was observed in Group B. Conclusion: PRF application has a positive effect on nerve recovery after anastomosis. Significance: Contribute to the literature to improve nerve regeneration.