Simple, mild, and highly efficient synthesis of 2-substituted benzimidazoles and bisbenzimidazoles
Quimica Nova, cilt.37, sa.4, ss.643-647, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 4
- Basım Tarihi: 2014
- Doi Numarası: 10.5935/0100-4042.20140096
- Dergi Adı: Quimica Nova
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.643-647
- Anahtar Kelimeler: Benzimidazole, Microwave heating, Synthesis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Bilecik Şeyh Edebali Üniversitesi Adresli: Evet
Özet
A new convenient method for preparation of 2-substituted benzimidazoles and bis-benzimidazoles is presented. In this method, o-phenylenediamines were condensed with bisulfite adducts of various aldehydes and di-aldehydes under neat conditions by microwave heating. The results were also compared with results of synthesis by conventional heating under reflux. Structures of the products were confirmed by infrared, 1H-and 13C-NMR spectroscopy. Short reaction times, good yields, easy purification of products, and mild reaction conditions are the main advantages of this method.