Simple, mild, and highly efficient synthesis of 2-substituted benzimidazoles and bisbenzimidazoles
Quimica Nova, vol.37, no.4, pp.643-647, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 37 Issue: 4
- Publication Date: 2014
- Doi Number: 10.5935/0100-4042.20140096
- Journal Name: Quimica Nova
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.643-647
- Keywords: Benzimidazole, Microwave heating, Synthesis
- Open Archive Collection: AVESIS Open Access Collection
- Bilecik Şeyh Edebali University Affiliated: Yes
Abstract
A new convenient method for preparation of 2-substituted benzimidazoles and bis-benzimidazoles is presented. In this method, o-phenylenediamines were condensed with bisulfite adducts of various aldehydes and di-aldehydes under neat conditions by microwave heating. The results were also compared with results of synthesis by conventional heating under reflux. Structures of the products were confirmed by infrared, 1H-and 13C-NMR spectroscopy. Short reaction times, good yields, easy purification of products, and mild reaction conditions are the main advantages of this method.