Simple, mild, and highly efficient synthesis of 2-substituted benzimidazoles and bisbenzimidazoles

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Eren B., Bekdemir Y.

Quimica Nova, cilt.37, sa.4, ss.643-647, 2014 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5935/0100-4042.20140096
  • Dergi Adı: Quimica Nova
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.643-647
  • Anahtar Kelimeler: Benzimidazole, Microwave heating, Synthesis
  • Bilecik Şeyh Edebali Üniversitesi Adresli: Evet

Özet

A new convenient method for preparation of 2-substituted benzimidazoles and bis-benzimidazoles is presented. In this method, o-phenylenediamines were condensed with bisulfite adducts of various aldehydes and di-aldehydes under neat conditions by microwave heating. The results were also compared with results of synthesis by conventional heating under reflux. Structures of the products were confirmed by infrared, 1H-and 13C-NMR spectroscopy. Short reaction times, good yields, easy purification of products, and mild reaction conditions are the main advantages of this method.