Akademik Veri Yönetim Sistemi
Medeniyet Medical Journal, cilt.32, sa.4, ss.205-211, 2017 (Scopus)
In this study, we examined antibiotic susceptibility patterns and changes in methicillin resistance of staphylococci isolates from derived from various clinical specimens. Between 2010 and 2015 in our hospital, 21478 staphylococci strains (6317 S. aureus strains and 15161 coagulase-negative staphylococci (CNS) strains) isolated from various clinical specimens of patients followed up in services, and outpatient clinics were included in the study. In our study, 6317 (29.4%) strains were Staphylococcus aureus (S. aureus) and 15161 (70.6%) strains were (CNS) strains. The resistance rates to methicillin was significantly higher in CNS strains than in S. aureus strains (p<0.001). A significant decrease in the methicillin resistance rates of S.aureus strains was found over the years (p<0.001). The methicillin resistance rates in S.aureus strains and CNS strains ranged between 4.5% and 32.1% in outpatients, 14.5% and 47.4% in general services, 27.7% and 51.8% in intensive care units (ICU). In both Methicillin resistance rate was found to be higher in both S. aureus (p<0.001) and CNS strains (p<0.001) isolated from ICU rather than general services. The declining rates of methicillin resistance in staphylococci are encouraging, however measures should be taken to maintain this condition in the longer term. We believe that reduction in the resistance rates by rational use of antibiotics and implementation of infection control measures may be maintained.